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Refusing a necessary diagnostic tissue biopsy out of fear that local anesthetic or mechanical needle puncture spreads systemic cancer delays curative treatment and dramatically worsens overall survival (Johnson et al., 2017). True tumor tract seeding remains an exceptionally rare phenomenon primarily isolated to select mesothelioma or testicular malignancies, while standardized core needle biopsy remains the undisputed global benchmark for oncologic staging (Lapidot et al., 2025; NCCN, 2026). #D
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