San Francisco 49ers quarterback Brock Purdy is still making quite an impact in the state of Iowa despite being three years removed from his playing days for the Cyclones.

San Francisco 49ers quarterback Brock Purdy isn't letting early-season injuries shake his confidence. Although he has been without reigning NFL Offensive Player of the Year Christian McCaffrey for the first two games—McCaffrey will miss at least the next three with Achilles tendinitis—Purdy remains optimistic.

In Purdy's last seven starts, he has won four games, lost three, thrown six touchdown passes and six interceptions, fumbled once and posted a passer rating of 87. That's about as average as it gets. And he's playing on the best team in football.

Two NFC West teams renew their rivalry as we continue our NFL odds series with a 49ers-Rams prediction and pick.

The San Francisco 49ers and Los Angeles Rams have aspirations of winning the NFC West and making another Super Bowl run, but both are dealing with significant losses on offense entering Week 3 when they go head-to-head.

George Kittle could have to miss his first game of the season as the San Francisco 49ers take on the Los Angeles Rams on Sunday. Per ESPN's Adam

The San Francisco 49ers are facing another blow to their offense after star tight end George Kittle missed Thursday's practice with what ESPN and NFL Network reported to be hamstring