Viral reverse transcriptase (RT) plays a critical role in replication (e.g., retroviruses, that reverse transcribe RNA templates into complementary DNA) and genome mutations (e.g., diversity ...

Viral reverse transcriptase (RT) plays a critical role in replication (e.g., retroviruses, that reverse transcribe RNA templates into complementary DNA) and genome mutations (e.g., diversity ...

In 1978, scientists in the Netherlands not only detected reverse transcriptase but also photographed what looked like a retrovirus in cells from several patients with an uncommon kind of T-cell ...

Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition.

A controlled study of reverse transcriptase in serum and CSF of HIV-negative patients with ALS. Neurology. 2007 May 29;68(22):1944-6. PubMed. McCormick AL, Brown RH Jr, Cudkowicz ME, Al-Chalabi A, ...

A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of DNA polymerases. Scientists ...

However, these groups weren't able to trace this reverse transcriptase to a specific retrovirus, leaving some scientists in doubt whether retroviruses are involved in ALS.

Within activated B cells, the ERV are driven to express RNA copies of themselves, which in turn are copied into DNA by reverse transcriptase. The RNA copies of ERV are detected by the RIG-I ...

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and ...