Viral reverse transcriptase (RT) plays a critical role in replication (e.g., retroviruses, that reverse transcribe RNA templates into complementary DNA) and genome mutations (e.g., diversity ...

Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition.

Baldwin, E.T, et al. (2022) Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K ...

In this publication, we describe for the first time the crystal structure of an endogenous reverse transcriptase, one known as HERV-K RT, and show that it has remarkable similarities to HIV RT, a ...

Retroviruses like HIV use reverse transcriptase to make copies of their DNA from RNA, ... Each retrovirus has a distinct version of the enzyme, ...

Reverse transcriptase is an enzyme associated with retroviruses. The presence of this enzyme activity in serum therefore implies that a retrovirus may be involved in ALS.

Imamichi, T. et al. High-level resistance to 3-azido-3-deoxythimidine due to a deletion in the reverse transcriptase gene human immunodeficiency virus type 1. J. Virol. 74 , 1023–1028 (2000).

During his 36-year career at Cancer Center, Michael Emerman, PhD, made fundamental discoveries about HIV, the retrovirus that ...

Codexis, Inc. (NASDAQ: CDXS), a leading enzyme engineering company enabling the promise of synthetic biology, today announced the launch of its Codex® HiTemp Reverse Transcriptase for use in one ...