Calls for a paradigm shift in psychiatry, away from a classical medical model, are growing stronger. One proposal involves replacing the current system based on diagnostic categories, defined in terms ...

Gait apraxia affects a person's ability to start and coordinate walking. It occurs when something affects the brain's frontal ...

This correspondence between brain state and brain responsiveness (statedependent responses) is outlined at different scales from the cellular and circuit level, to the mesoscale and macroscale level.

We conclude that brain states are shaped by local circuit mechanisms, large-scale connectivity and neuromodulation. A unified multiscale theory of cortical dynamics is relevant not only for ...