Now A*STAR researchers have identified how the build-up of monosodium urate (MSU) crystals in the joints triggers such excruciating pain, raising the prospect of new treatments.

Human exposure to toxic particles drives various diseases. Examples include gout, an acute arthritis driven by monosodium urate crystals, or MSUc; CPPD disease, another inflammatory joint disease ...

Monosodium urate crystals dissolve and are eliminated from joints and soft tissues as serum uric acid levels drop below its saturating point (400 μmol/l). Time to crystal clearance relates to ...

WASHINGTON — Different stages of gout treatment may call for different serum urate targets, with certain levels being better for dissolving or preventing monosodium urate crystals, according to ...

It turns out that amorphous urate crystals had been deposited in the man's cardiomyocytes, potentially causing a strong inflammatory reaction and cell death. "We identified monosodium urate ...

“Our model is now validated for monosodium urate and calcium pyrophosphate crystals, but can also easily be applied for basic calcium phosphate crystals, such as hydroxyapatite,” he said.

The study was triggered by the observation of tiny tissue fragments containing organised deposits of monosodium urate crystals.

Monosodium urate (MSU) crystal deposits correlate with the degree of bone erosion displayed on dual-energy computed tomography (DECT), which may identify gout progression and joint damage earlier.

Can monosodium urate crystal deposition ultrasound findings at certain joints predict future gout flares over 12 months in patients initiating urate-lowering therapy? Ultrasound features of MSU ...

Demonstrating the presence of monosodium urate (MSU) crystals in the joint fluid or tophus has been the gold standard for the diagnosis of gout. However, many physicians do not perform synovial ...