Background CDH1 is commonly mutated in sporadic diffuse gastric cancer (DGC) and germline CDH1 mutations underlie most cases of the cancer syndrome hereditary DGC. Objective We aimed to develop mouse ...
Introduction: Physical exercise induces physiological cardiac growth and protects the heart against pathological stresses. However, the molecular mechanisms underlying these cardiac benefits of ...
A potentially crippling medical condition, often dismissed by healthcare providers, can no longer be ignored. “Floxing”—a term for the adverse effects of fluoroquinolone antibiotics—has been ...
The APOE Christchurch mutation attenuated amyloid pathology in the brains of mice who had received intracerebral injections of AD tau fibrils. Plaque pathology was evaluated using the fluorescent dye ...
Parkinson’s disease (PD) affects millions globally, disrupting motor function and quality of life. While roughly 10% of cases are linked to genetic mutations, the majority result from complex ...
Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...
EMCN (endomucin), an endothelial-specific glycocalyx component, was found to be highly expressed by the endothelium of the renal glomerulus. We reported an anti-inflammatory role of EMCN and its ...
This transgenic mouse model expresses a floxed ATPase type 13A2 (Atp13a2) gene, with loxP sites flanking exons 2 to 3 (The Jackson Laboratory). The ATP13A2 protein is a transmembrane lysosomal ATPase ...
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