C re-loxP recombination allows scientists to excise, insert, or invert specific DNA segments with unprecedented accuracy. 1,2 This works through two key components: a Cre recombinase and loxP sequence ...

On November 14, 2023, a new editorial was published in Oncoscience, entitled, “Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research.” ...

Researchers at the University of Tsukuba have developed a vector that integrates the Cre enzyme gene with the specific DNA sequence loxP, which is its target. This vector allows the creation of ...

Cre mice, conditional gene knockout mice in which the Cre/loxP recombination system is employed, have become the new standard in genetics research. ... transgene type, and genetic background.

A new editorial paper was published in Oncoscience (Volume 10) on November 14, 2023, entitled, "Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research." ...

Tsukuba, Japan—Organisms modified via the introduction of the Cre-loxP system (Cre-loxP organisms) are widely used in life sciences to investigate the function of specific genes.