For people with cerebral amyloid angiopathy (CAA), the heightened risk of ARIA, i.e., inflammation around blood vessels, may outweigh any potential gains of anti-amyloid immunotherapy. But with about ...

Could stem cells step in to replace lost neurons in Parkinson’s disease? In three Phase 1 clinical trials, scientists tested lab-grown dopaminergic cells in small cohorts to assess safety and look for ...

Whether a person eats a cookie or devours the whole box could come down to the mood of microglia in their hypothalamus. Blocking activation of the region’s NLRP3 inflammasome could keep excessive ...

Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...

In the Alzheimer’s brain, microglia diversify into several activation states. What controls this specialization? In a preprint posted to bioRxiv on October 13, scientists led by Martin Kampmann at the ...

Retrotransposons are evolutionarily ancient genes that “jump” around the human genome leaving a slew of repeat nucleotide sequences in their wake. These repeats can disturb normal gene function.

As anti-amyloid approaches continue to yield meager benefits for people with Alzheimer’s disease, therapies targeting neurofibrillary tangles are getting more attention. In the October 1 Nature ...

In amyotrophic lateral sclerosis and frontotemporal dementia, loss of nuclear TDP-43 mucks up splicing of many transcripts, squelching expression of the associated proteins. However, this missplicing ...

For decades, scientists have measured how specific regions of the brain shrink with age and disease. Other studies have tracked widening sulci or enlarging ventricles. But is parenchymal shrinkage the ...

Scientists know that most people with Alzheimer’s disease also have other pathologies in the brain. They don’t know how much the latter contributes to cognitive problems. In the September 10 Nature ...

This widely used tauopathy model was developed at the University of Pennsylvania School of Medicine by Virginia Lee, John Trojanowski, and colleagues. As first reported in 2007 on a mixed background, ...

Multiple streams of evidence converge on a central role for lipid metabolism in neurodegenerative diseases. With an apolipoprotein as its top genetic risk factor, sporadic Alzheimer’s disease is no ...