Now A*STAR researchers have identified how the build-up of monosodium urate (MSU) crystals in the joints triggers such excruciating pain, raising the prospect of new treatments.

Human exposure to toxic particles drives various diseases. Examples include gout, an acute arthritis driven by monosodium urate crystals, or MSUc; CPPD disease, another inflammatory joint disease ...

Gout is a crystal arthropathy and is the most common inflammatory arthritis in adults. Spinal involvement is observed in 17% of gout patients and may still be under-recognized. MRI is sensitive, but ...

Abstract and Introduction Abstract. Monosodium urate crystals dissolve and are eliminated from joints and soft tissues as serum uric acid levels drop below its saturating point (400 μmol/l).

WASHINGTON — Different stages of gout treatment may call for different serum urate targets, with certain levels being better for dissolving or preventing monosodium urate crystals, according to ...

The study was triggered by the observation of tiny tissue fragments containing organised deposits of monosodium urate crystals. Findings show that crystals form at the cartilage surface, as well ...

Ultrasound features of monosodium urate (MSU) crystal deposition in index joints at baseline were predictive of future gout flares in the same joints among patients initiating urate-lowering ...

There was 96% accuracy in the classification of calcium pyrophosphate crystals using the 2023 ACR/EULAR CPPD classification criteria (95% CI, 92.3-98.3), and 92.5% accuracy with monosodium urate ...

"We identified monosodium urate crystals by histology, electron microscopy, and negative birefringence on exposure of a frozen myocardial sample to polarized light," Frustaci's team said.

Monosodium urate (MSU) crystal deposits correlate with the degree of bone erosion displayed on dual-energy computed tomography (DECT), which may identify gout progression and joint damage earlier.