Researchers identify FGFR4, FLT1, and WNT5A as key biomarkers and suggest dovitinib and nintedanib as new targeted therapies ...

Humans have about 400 odorant receptors (ORs), but scientists have had trouble finding ligands that match up with most of ...

Cancer remains a leading cause of global morbidity and mortality. Traditional therapies like chemotherapy and radiotherapy are often limited by their ...

Scientists have discovered the brain’s hidden “off switch” for hunger, and it could revolutionize the fight against obesity.

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

Discusses ESMO Data on TGF-beta Receptor by PD-1 Bispecific in Colorectal Cancer and G12D Inhibitor in Pancreatic ...

US FDA grants priority review for Keytruda & Keytruda Qlex, each in combination with Padcev, for certain patients with muscle-invasive bladder cancer: Rahway, New Jersey Friday, O ...

A UCL-led study shows nanoparticles can restore blood-brain barrier function and clear amyloid-β in mice, reversing Alzheimer ...

Researchers have identified two experimental medications that may be able to promote myelin repair in people with MS, a study ...

FX-909 has achieved clinical proof of concept in the Phase 1A trial as a monotherapy, and we are very pleased to announce this agreement with Merck to add a combination arm to our ongoing Phase 1 ...