Gene therapy with lentiviral vector–transduced HSCs, as compared with AAV gene therapy, for hemophilia A overcomes nearly all the limitations related to highly variable and unpredictable ...

Today, the standard treatment for HIV is antiretroviral therapy (ART) — a combination of HIV medications, typically taken daily, that disrupt the virus’s replication cycle.

Conclusions At a median follow-up of 6 years after lentiviral gene therapy, most patients with early cerebral adrenoleukodystrophy and MRI abnormalities had no major functional disabilities.

The LV Edge Packaging System has recently been launched to improve cost efficiency and reduce the supply chain risk of lentiviral production. The company claims the ready-to-transfer system ...

Rapid, Sensitive, and Validated Detection of Viral Replication Genes Using Droplet Digital™ PCR During Cell and Gene Therapy Production.

The kits provide rapid, cost-effective solutions for the absolute quantification of replication competent lentivirus (RCL) and replication competent adeno-associated virus (RCAAV), supporting the safe ...

Contract development and manufacturing organisation (CDMO) Genezen has announced plans to license CSL’s Cytegrity stable lentivirus production system. The advanced inducible technology produces ...

Dysregulation of this network highlights a novel mechanism of cell cycle control during KSHV lytic replication in B cells. Importantly, disruption at any point within this novel ncRNA regulatory ...

Although the cell cycle is strictly regulated, a growing number of viruses have been demonstrated to evolve diverse strategies of utilizing the components of cell cycle to facilitate their own ...

Break‐induced replication (BIR) mediates recombination where DNA strand homology is limited to one end of donor sequence. Here, the helicase PIF1 is found to play a critical BIR role in mammalian ...

Researchers have studied SARS-CoV-2 replication in cells and obtained detailed insights into the alterations induced in infected cells. This information is essential to guide the development of ...

To limit cross-species lentiviral transmission, cellular "intrinsic immunity," including APOBEC3 proteins potentially inhibit lentiviral replication.