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Study Reveals Why Cells Senesce Earlier Under High Oxygen Conditions
A new study demonstrates that replicative senescence depends upon ATM kinase, and that high oxygen generates a hyperactive ...
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CDT1 overexpression suppresses DNA replication and triggers DNA damage linked to cancer, finds study
A research group has demonstrated that overexpression of Cdc10-dependent transcript 1 (CDT1), a key regulator of DNA ...
DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among ...
An international research team has identified a human protein, ANKLE1, as the first DNA-cutting enzyme (nuclease) in mammals ...
News-Medical.Net on MSN
New method reveals how human cells initiate DNA replication
When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...
The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both ...
Scripps Research scientists have discovered how some tumors endure DNA damage, revealing a potential new way to target them. The DNA inside our cells is constantly exposed to damage, and one of the ...
High-resolution imaging has revealed the internal layout of chromatin condensates, showing how DNA fibers fold and interact ...
AZoLifeSciences on MSN
Study uncovers principles guiding replication initiation across the human genome
When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...
Inside human cells, biology has pulled off the ultimate packing job, figuring out how to fit six feet of DNA into a nucleus ...
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