On November 14, 2023, a new editorial was published in Oncoscience, entitled, “Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research.” ...

Organisms modified via the introduction of the Cre-loxP system (Cre-loxP organisms) are widely used in life sciences to investigate the function of specific genes. Cre is a type of DNA ...

Cre- loxP recombination allows scientists to excise, insert, or invert specific DNA segments with unprecedented accuracy. 1,2 This works through two key components: a Cre recombinase and loxP sequence ...

A new editorial paper was published in Oncoscience (Volume 10) on November 14, 2023, entitled, "Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research." In this new ...

Chances are if you use mice in your research, you are intimately acquainted with the Cre/LoxP recombination system. (For the uninitiated out there, this is a system to achieve tissue- or cell type ...

That was so last season!) Cre mice, conditional gene knockout mice in which the Cre/loxP recombination system is employed, have become the new standard in genetics research.