Researchers have created nanoparticles that can remove disease-driving proteins while also delivering a chemotherapeutic or ...

An illustration of one of Grove Biopharma’s protein-like polymers in sky blue and bright yellow. These protein-like polymers may help target intractable cancer-causing proteins. Credit: Saeed Najafi, ...

For years, a protein inside our cells has quietly powered billions of dollars' worth of cancer drugs. Now a team of ...

Can you please introduce yourself and your role at LifeArc? As part of my Biochemistry degree at University of Leeds, I completed an industry placement at LifeArc. This was my first introduction to ...

Orum Therapeutics (“Orum” or the “Company”) (KRX: 475830), a biotechnology company pioneering the field of degrader antibody ...

A new active substance attacks a key protein in tumor cells, leading to complete degradation. In cell experiments, this caused cancer cells to lose their protection and die. The active substance was ...

Targeted protein degradation (TPD) therapy is a promising new class of targeted treatments. Based on a cell’s natural mechanism for eliminating diseased proteins, this therapy can combat hard-to-treat ...

Targeted protein degradation (TPD) approaches including PROTAC and molecular glue have revolutionized drug discovery. However, in part due to complication of the ubiquitination and related ...

Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. ...

BACKGROUND: Aortic valve calcification increases leaflet stiffness and contributes to the development of calcific aortic valve disease. The molecular and cellular mechanisms underlying calcification ...