Hdy-7 directly binds to TrxR1/2, triggering ROS accumulation and p53 activation. Activated p53 negatively regulates mTORC1 signaling, which is one of the major kinases responsible for the ...
The study investigated r ezatapopt (PC14586), a first-in-class small molecule designed to selectively bind and reactivate the ...
A phase I study of allogeneic anti-CD19 CAR-T therapy for patients with CD19+ relapsed/refractory acute B-lymphoblastic leukemia. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I.
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