Ms. Psaki, 46, will host a show at 9 p.m. Tuesday through Friday, replacing Alex Wagner, a longtime political journalist who has anchored that hour since 2022, according to a memo to staff from Rebecca Kutler, MSNBC’s president. Ms. Wagner will remain at MSNBC as an on-air correspondent.

MSNBC confirmed plans to overhaul its daytime, primetime and weekend lineup, with Jen Psaki and the three anchors of The Weekend — Symone Sanders Townsend, Michael Steele and Alicia Menendez — getting primetime shows.

Jen Psaki, the former Biden White House press secretary who has become a favorite at MSNBC since joining in 2023, will get even more screen time in front of viewers in April when she takes over the network's 9 p.