Tail-anchored (TA) membrane proteins are targeted to the endoplasmic reticulum (ER) post-translationally by the guided entry of TA proteins (GET) pathway; this involves the formation of a complex ...

A crucial step in preclinical drug development is the confirmation of the novel therapeutic molecule's specific binding to the targeted protein. Transmembrane proteins (TPs) like ion channels, ...

This is a preview. Log in through your library . Abstract We have investigated the topology of the α and δ subunits of the nicotinic acetylcholine receptor (AChR) from mammalian muscle synthesized in ...

This study demonstrates the power of a genetic selection to identify a variant virus that uses a new retroviral receptor protein. We screened a random peptide library within the receptor-binding ...