RNA polymerases are sloppy. A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of ...

View Full Profile. Learn about our Editorial Policies. Prime editing uses specialized machinery consisting of a prime editing guide RNA (pegRNA) and a Cas9 enzyme fused to a reverse transcriptase. The ...

In order for HIV to replicate, it uses an enzyme called reverse transcriptase to translate its viral RNA into double-stranded DNA, which is then integrated into the nucleus of the host cell to ...

it is the first nucleotide analogue reverse-transcriptase inhibitor marketed in the United States for the management of HIV infection. It is indicated for use in combination with other ...

Again, the selectivity of the inhibitory activity of AZT for a viral enzyme — HIV reverse transcriptase — compared ... a therapeutic window for its use. Two key advances in the 1980s ...

Nucleoside reverse transcriptase inhibitors (NRTIs), and nucleotide ... Protease inhibitors (PIs) block the activity of the protease enzyme, which HIV uses to break up large polyproteins into the ...