The Tennessee Titans, led by quarterback Cam Ward, face the San Francisco 49ers, led by quarterback Brock Purdy, on Sunday, Dec. 14, 2025 at Levi’s Stadium in Santa Clara, Calif.

Tennessee lost 37-24 to the San Francisco 49ers on Dec. 14 at Levi's Stadium, with the 49ers scoring on their first five drives and seven of eight possessions overall. Brock Purdy threw for 295 yards and three touchdowns, while Murfreesboro's Jauan Jennings caught two touchdown passes.

The NFL season continues in Week 15 when the San Francisco 49ers host the Tennessee Titans on Sunday. Start time, how to watch, stream and NFL TV schedule.

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the team’s fourth win in a row.

Learn which TV channel or how to live stream the NFL Week 15 San Francisco 49ers and Tennessee Titans game, Sunday, Dec. 14.

Watch the top plays from Seattle's Week 12 matchup with the Tennessee Titans. Seattle Seahawks linebacker DeMarcus Lawrence tackles Tennessee Titans running back Tyjae Spears behind the line of scrimmage for a 4-yard loss during Sunday's Week 12 game.

Offensive tackle Dan Moore Jr., who missed the Week 15 loss to the San Francisco 49ers, returned to practice and was a full participant. The bad news was that Cedric Gray (concussion), Amani Hooker (illness), Van Jefferson (back), and Kevin Zeitler (groin) all sat out practice due to their injuries.

Learn which TV channel or how to live stream the NFL Week 14 Cleveland Browns and Tennessee Titans game, Sunday, Dec. 7.