Nature

Accurate liability estimation improves power in ascertained case-control studies

In recent years, genome-wide association studies (GWAS) have uncovered thousands of risk variants for genetic traits 1. However, only a small fraction of disease variance is explained by discovered ...
JSTOR Daily

Sample Size Determination for Multiple Continuous Risk Factors in Case- Control Studies

For a desired power of detecting the association between a disease and several potential risk factors in case-control studies, Yang (1978, Biometrika 65, 635-640) and Halperin (1980, Biometrika 67, ...
JSTOR Daily

Semiparametric Maximum Likelihood Estimation Exploiting Gene-Environment Independence in Case-Control Studies

This is a preview. Log in through your library . Abstract We consider the problem of maximum-likelihood estimation in case-control studies of gene-environment associations with disease when genetic ...
ascopubs.org

Bayesian Sample Size Planning Tool for Phase I Dose-Finding Trials

Implementation of the Time-to-Event Continuous Reassessment Method Design in a Phase I Platform Trial Testing Novel Radiotherapy-Drug Combinations—CONCORDE BayeSize applies the concept of effect size ...
Nasdaq

Trevi Therapeutics Announces Positive Outcome of the Sample Size Re-Estimation Analysis in PRISM Trial for Severe Pruritus in Patients With Prurigo Nodularis

NEW HAVEN, Conn., July 13, 2020 (GLOBE NEWSWIRE) -- Trevi Therapeutics, Inc. (Nasdaq: TRVI), a clinical-stage biopharmaceutical company focused on the development and commercialization of Haduvio ...