Viral reverse transcriptase (RT) plays a critical role in replication (e.g., retroviruses, that reverse transcribe RNA templates into complementary DNA) and genome mutations (e.g., diversity ...

Retroviruses like HIV use reverse transcriptase to make copies of their DNA from RNA, the opposite of how genetic information is usually processed in cells.

In a study published last summer, Greenbaum, Burns, and their colleagues found that a reverse transcriptase inhibitor slowed the progression of metastatic colorectal cancer in 9 of 32 patients with ...

Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition.

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer ...

During his 36-year career at Cancer Center, Michael Emerman, PhD, made fundamental discoveries about HIV, the retrovirus that ...

ROME Therapeutics announced a publication in PNAS which describes the first X-ray crystallography structure of an endogenous reverse transcriptase.

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer ...

Through rational structure-based drug design, ROME identified novel, selective and potent inhibitors of LINE-1 reverse transcriptase.

Sequence variations in human immunodeficiency virus (HIV)-1 reverse transcriptase (RT) and protease, the molecular targets of anti-retroviral drug therapy, are prime examples of genes in which ...