Viral reverse transcriptase (RT) plays a critical role in replication (e.g., retroviruses, that reverse transcribe RNA templates into complementary DNA) and genome mutations (e.g., diversity ...

Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition.

Baldwin, E.T, et al. (2022) Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K ...

In this publication, we describe for the first time the crystal structure of an endogenous reverse transcriptase, one known as HERV-K RT, and show that it has remarkable similarities to HIV RT, a ...

Retroviruses like HIV use reverse transcriptase to make copies of their DNA from RNA, ... Each retrovirus has a distinct version of the enzyme, ...

During his 36-year career at Cancer Center, Michael Emerman, PhD, made fundamental discoveries about HIV, the retrovirus that ...

Reverse transcriptase is an enzyme associated with retroviruses. The presence of this enzyme activity in serum therefore implies that a retrovirus may be involved in ALS.

Imamichi, T. et al. High-level resistance to 3-azido-3-deoxythimidine due to a deletion in the reverse transcriptase gene human immunodeficiency virus type 1. J. Virol. 74 , 1023–1028 (2000).

Codexis, Inc. (NASDAQ: CDXS), a leading enzyme engineering company enabling the promise of synthetic biology, today announced the launch of its Codex® HiTemp Reverse Transcriptase for use in one ...