Viral reverse transcriptase (RT) plays a critical role in replication (e.g., retroviruses, that reverse transcribe RNA templates into complementary DNA) and genome mutations (e.g., diversity ...

RNA polymerases are sloppy. A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of ...

These so-called endogenous retroviruses could then be transcribed into virus-like ... via an RNA intermediate and reinsert into the genome. LINE-1 also encodes a reverse transcriptase protein, which ...

Is working to synthesize such components to block retrovirus nucleic acid expression and oncogenes ... Also has developed a new reverse transcriptase inhibitor called "ADAM," and analogs of it are ...

Data from two studies suggest that a once-daily combination therapy of doravirine and islatravir was noninferior to current, ...

A recent study has identified a triple stranded HIV cDNA intermediate of reverse transcription ... nucleic acids must access the nucleus. For retroviruses in general, viral nucleic acids seem ...

How did viruses evolve? Are they a streamlined form of something that existed long ago, or an ultimate culmination of smaller genetic elements joined together?

Switching to islatravir and doravirine was just as effective as bictegravir/emtricitabine/tenofovir alafenamide fumarate (BIC ...