RNA polymerases are sloppy. A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of ...

as they target the reverse transcriptase enzyme that the virus uses to replicate its genetic material. Among these inhibitors, islatravir has emerged as a promising candidate due to its unique ...

Gilead Sciences announced a significant milestone: the U.S. FDA accepted their New Drug Applications (NDAs) for lenacapavir ...

In order for HIV to replicate, it uses an enzyme called reverse transcriptase to translate its viral RNA into double-stranded DNA, which is then integrated into the nucleus of the host cell to ...

It is an ester-derived prodrug that is converted in vivo by serum and tissue esterases to tenofovir, an acyclic nucleoside phosphonate (nucleotide) that inhibits HIV reverse transcriptase.

These viruses encode a reverse transcriptase enzyme that converts the RNA genome into DNA during the retroviral life cycle, which then becomes integrated into the host genome. HIV-1 TAR RNA plays ...

A retroviral enzyme which converts genetic material from RNA into DNA, an essential step in the lifecycle of HIV. Several classes of anti-HIV drugs interfere with this stage of HIV’s life cycle: ...