The hypothalamus–pituitary–target gland axis has been recognized as a fundamental functional framework of the mammalian endocrine system. The anterior pituitary gland synthesizes and secretes multiple ...

Subtle to frank abnormalities in hypothalamic–pituitary axis function are frequently seen in cancer survivors who have received prophylactic or therapeutic cranial irradiation. The growth hormone (GH) ...

A new case report describes a pembrolizumab-treated patient who developed primary hypothyroidism from immune thyroid ...

An unexpected observation has led researchers at the Weizmann Institute of Science to challenge a 200-year-old doctrine regarding the embryonic origins of the pituitary gland. Situated at the base of ...

The pituitary gland is a small organ at the base of the brain responsible for hormone production. Specifically, it regulates chemical messages throughout t | Endocrine System ...

Located at the base of the brain, nestled within the skull, lies a bean-shaped endocrine gland called the pituitary. It’s as small as a pea and just about as light – weighing only half a gram. But ...

A new review argues that chronic kidney disease may dysregulate pituitary hormones through uremic toxins, inflammation, disrupted FGF23-Klotho signaling, microRNAs, and gut-brain pathways.

A team of researchers at the IRCM, supervised by Dr. Jacques Drouin, reprogrammed the identity of cells in the pituitary gland and identified critical mechanisms of epigenetic cell programming. This ...

Changes clinical practice: Adults who received cranial radiotherapy for nonpituitary tumors should have their hypothalamic-pituitary axis periodically evaluated. This is the first meta-analysis of ...

Background A 61-year-old lady was admitted to hospital with sepsis due to a urinary tract infection. Three days after admission, she suddenly started to have severe headache with visual disturbance ...

For permission requests, please contact NEJM Reprints at [email protected] In spite of great progress in the knowledge of the chemistry and physiologic function of the pituitary hormones no truly ...

As October is Pituitary Awareness Month, let's highlight one of the most important – yet least well-known – organs in the ...