Now A*STAR researchers have identified how the build-up of monosodium urate (MSU) crystals in the joints triggers such excruciating pain, raising the prospect of new treatments.

Abstract and Introduction Abstract. Monosodium urate crystals dissolve and are eliminated from joints and soft tissues as serum uric acid levels drop below its saturating point (400 μmol/l).

WASHINGTON — Different stages of gout treatment may call for different serum urate targets, with certain levels being better for dissolving or preventing monosodium urate crystals, according to ...

The study was triggered by the observation of tiny tissue fragments containing organised deposits of monosodium urate crystals. Findings show that crystals form at the cartilage surface, as well ...

There was 96% accuracy in the classification of calcium pyrophosphate crystals using the 2023 ACR/EULAR CPPD classification criteria (95% CI, 92.3-98.3), and 92.5% accuracy with monosodium urate ...

Ultrasound features of monosodium urate (MSU) crystal deposition in index joints at baseline were predictive of future gout flares in the same joints among patients initiating urate-lowering ...

Monosodium urate (MSU) crystal deposits correlate with the degree of bone erosion displayed on dual-energy computed tomography (DECT), which may identify gout progression and joint damage earlier.

"We identified monosodium urate crystals by histology, electron microscopy, and negative birefringence on exposure of a frozen myocardial sample to polarized light," Frustaci's team said.

Bomalaski JS, Lluberas G, Schumacher HR Jr. Monosodium urate crystals in the knee joints of patients with asymptomatic nontophaceous gout. Arthritis Rheum. 1986;29:1480-1484. 25.

Serum urate levels significantly mediated the association between carbohydrate consumption and the risk of gout. Conclusion The study found that carbohydrates prevent gout, whereas free sugars ...