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Mendelian randomization is not affected by the confounding inherent in observational studies but it does rely on several assumptions, which can be hard to test Mendelian randomization can provide a ...

Mendelian randomization is a study design that uses genetic variants as instrumental variables to test the causal effect of a (non-genetic) risk factor on a disease or health-related outcome. Since ...

Inflammatory bowel disease and elevated BMI may play causal roles in hidradenitis suppurativa, results of a Mendelian ...

Increased BMI and IBD have causal effects on the risk of hidradenitis suppurativa, as shown by Mendelian randomization ...

Coffee is alternately championed and derided for its health effects. A new study introduces the genetics of caffeine metabolism into the conversation. In the ongoing battle over the benefits or risk ...