G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

Humans have about 400 odorant receptors (ORs), but scientists have had trouble finding ligands that match up with most of ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

Cancer remains a leading cause of global morbidity and mortality. Traditional therapies like chemotherapy and radiotherapy ...