A new Drosophila cancer atlas called ART-D maps ten genetically defined Ras-driven tumor models through three stages of ...

CHOP uncovers genetic link to neurodevelopmental disorder by identifying MAP2K4 variants affecting the JNK pathway in patients with developmental delays.

Researchers identified 10 individuals with rare MAP2K4 variants and used gene-edited neuron models to study disease ...

Discovered in the 1990s, the JNK protein, or, to give it its full name, c-Jun NH 2-terminal kinase, was found to be the protein kinase responsible for the phosphorylation of c-Jun at Ser-63 and Ser-73 ...

Morphologic and genomic characterization of circulating tumor cells in patients with metastatic colorectal cancer treated with combinational treatment of andecaliximab, bevacizumab and chemotherapy.

Researchers from Children's Hospital of Philadelphia (CHOP) have discovered the mechanisms of previously unknown ...

Glial phagocytosis of superfluous neurons and damaged or aberrant neuronal material is crucial for normal development and maintenance of the CNS. However, the molecular mechanisms underlying the ...

Neurons, with their large cell bodies and extensive processes, depend on a delicately balanced intracellular transport machinery to keep in touch with their own outer reaches. Inequalities between ...