For decades, methotrexate has formed the foundation of therapy in RA, either alone or in combination with other drugs; however, its mechanisms of action remain poorly understood, and many patients ...

Researchers have discovered that the enzyme NUDT5 utilizes its structure to exercise metabolic control over a key pathway in ...

Researchers analyzed the role of NUDT5 and its interaction with other proteins in the folate pathway and in regulating purine synthesis.

Modern dietary patterns and genetic factors contribute to nutrient deficiencies, including folate. Neupril’s products are ...

Several different causes of aging have been discovered, but the question remains whether there are common underlying mechanisms that determine aging and lifespan. Researchers from the Max Planck ...

Just when you thought you had your vitamins figured out, science throws us a curveball. New research from Texas A&M University is challenging everything we thought we knew about folate (that’s vitamin ...

Impact of first-line bevacizumab (BV) on the clinical outcomes of patients with metastatic colorectal cancer (mCRC) treated with second-line FOLFIRI plus BV. Evaluating magnetic resonance imaging (MRI ...

A surprising discovery reveals how a single protein helps cells decide when to make the building blocks of DNA. Researchers ...

BOSTON (November 10, 2008) — Researchers at Tufts University have gained further understanding of the genomic basis for altered folate metabolism and the content of uracil in blood DNA. In a study ...

Multicenter phase I/II trial of topotecan (T) and ifosfamide (I) combination as second-line therapy for pediatric solid cancer: Phase II results. This is an ASCO Meeting Abstract from the 2013 ASCO ...

The novel beta-coronavirus virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronaviruses, in general, alter the host's cellular metabolism to support massive production of ~30 ...

This is a preview. Log in through your library . Abstract Rats were subjected to deprivation of vitamin B₁₂ in order to induce neuropathy and to study effects on folate metabolism. Plasma vitamin B₁₂ ...