The transverse tubules (t-tubules) are invaginations of the cell membrane rich in several ion channels and other proteins devoted to the critical task of excitation-contraction coupling in cardiac ...

L-type Ca²⁺ currents determine the shape of cardiac action potentials (AP) and the magnitude of the myoplasmic Ca²⁺ signal, which regulates the contraction force. The auxiliary Ca²⁺ channel subunits ...

The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...

The congenital myopathies are a group of early-onset, non-dystrophic neuromuscular conditions with characteristic muscle biopsy findings, variable severity and a stable or slowly progressive course.