When chemists need to separate one chiral molecule from a mixture of enantiomers—for instance, when synthesizing potential drug molecules—they often turn to high-performance liquid chromatography ...

Separations using tiny polymer-based devices could offer an alternative to chromatography for purifying of chiral compounds. Serena Arnaboldi of the University of Milan and coworkers initially ...

From 2001 to 2011, the US Food and Drug Administration approved 9 single-enantiomer drugs with racemic precursors. None showed pre-approval evidence of improved efficacy over the racemic precursor. We ...

Researchers of Tomsk Polytechnic University collaboratively with colleagues from the Czech Republic developed supersensitive sensors for detecting enantiomers, known as 'mirror molecules', in drugs.

Many chemical compounds exist in two variants, called enantiomers. These consist of the same elements but act as mirror images of each other. In reference to our hands, which are also mirror images, ...

(±)Doxazosin is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. In this study we investigated the ...

Many organic molecules are non-superimposable with their mirror image. The two forms of such a molecule are called enantiomers and can have different properties in biological systems. The problem is ...

The vast majority of new small-molecule drug candidates are chiral, and methods must be identified for obtaining the desired enantiomer in high purity. A common approach is to separate the enantiomers ...

Thalidomide, one of the most infamous drugs of all, caused severe birth defects in the children of pregnant women who took the drug for nausea in the 1950s. Its story has been repeated over and over – ...

Stereochemistry relates to the spatial organization of atoms in a molecule. Often molecules having the same chemical makeup can exist in different spatial arrangements. These related molecules are ...