Despair is the trickiest affliction to handle because of its "instant death" effect. You have to deal with this malady in certain areas, such as the mining tunnel past the Snowy Passage, the caverns ...

Marine scientists indeed call a deep-sea brine pool off the eastern coast of Mexico a "Jacuzzi of Despair" or "Hot Tub of Despair." While it's true that most organisms that enter the water will die ...