Run the likes of Civilization and Daggerfall as God intended, now easily loaded directly from ZIP files.
The major benefit I see in DOSBox Pure over DOSBox Classic is a sort of built-in containerization for games. DOSBox Pure creates a separate environment for each game automatically when it's "opened" ...
would it not be epic to play command and conquer / redalert / warcraft / starcraft on the wii just replace the mouse input with the wii mote control scheme and up date the graphics just a little using ...
Maybe you're not getting the true retro PC experience if you're not fiddling with settings at an emulated DOS text prompt, but there's something to be said for how easy console emulation has become ...