Global understanding of complement has shifted and developed since the 21st century: from our idea of a blood-based antibiotic system to a global regulator of immunity and tissue homeostasis. Recent ...

When drug development and the immune system collide we get CAR-T, checkpoint inhibitors, oncolytic vaccines, monoclonal antibodies and more. These fields have produced many therapies and garnered a ...

Dysregulation of the complement cascade is implicated in the pathogenesis of several inflammatory and allergic disorders, such as arthritis, ischaemia–reperfusion injury and asthma. In a study ...

In a recent study posted to the bioRxiv* pre-print server, researchers investigated the complement component 1q (C1q) binding and subsequent complement activation by neutralizing antibodies (nAbs) ...

November 21, 2011 — The cartilage damage associated with osteoarthritis (OA) is in part a result of dysregulation of the complement system, Qian Wang, MD, PhD, and colleagues reported in an article ...

CRESTWOOD, Ky. and WALTHAM, Mass., July 18, 2019 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals Inc., (Nasdaq:APLS) a clinical-stage biopharmaceutical company focused on the development of novel ...

Most people are familiar with the immune system and its role in protecting against diseases and infection. But what about the complement system? The complement system is a foundational part of the ...

Frequent kidney dialysis can cause systemic inflammation, leading to complications such as cardiovascular disease and anemia by triggering the complement cascade, part of the innate immune system.

In view of the importance of complement system in the initiation, regulation and end effects of immune responses and understanding of immune system as one of the targets for the toxic effects of ...

With Alzheimer’s disease therapies finally reaching the market and hundreds of active clinical trials for therapies and diagnostics, it seems like every week brings another potential avenue to explore ...