The cellular and molecular mechanisms that lend AJs this versatility are not well understood, but the actin motor, myosin II, has previously been implicated in AJ assembly and function 1. Now, on page ...

Over the last several years the identification and functional characterization of the motor proteins actin and myosin in the nucleus has initiated a change in the view of nuclear processes. It is now ...

During each heartbeat, cardiac contractility results from calcium-activated sliding of actin thin filaments toward the centers of myosin thick filaments to shorten cellular length. Cardiac ...

The actin and myosin complex (actomyosin) generates contraction force of a muscle utilizing the adenosine triphosphate (ATP) hydrolysis reaction. Many attempts have thus been made to explain the ...

Dilated cardiomyopathy (DCM) leads to heart failure, a leading cause of death in industrialized nations. Approximately 30% of DCM cases are genetic in origin, with some resulting from point mutations ...

Hypertrophic cardiomyopathy (HCM) is a common genetic disorder characterized by left ventricular hypertrophy and cardiac hyper-contractility. Mutations in the β cardiac myosin heavy chain gene (β-MyHC ...

Physicists from the Universities of Bayreuth and Grenoble have discovered a new mechanism of cell mobility. Their findings challenge the classical dogma that the molecular motor myosin is essential ...

Some cells, such as immune cells, are highly mobile—they constantly remodel their shape, migrate toward a wound that needs to be closed or chase down bacteria in the bloodstream. This mobility is ...