The Cleveland Guardians (40-48) and the Houston Astros (55-35) open a 3-game series Monday at Daikin Park in Houston. First pitch is scheduled for 8:10 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Guardians vs. Astros odds and make our expert MLB picks and predictions for the best bets.

After sweeping the Los Angeles Dodgers, the Astros return home to open a series against the Cleveland Guardians who have lost 10 in a row.

Guardians update (40-47): They lost their 10th straight game Sunday as the Tigers completed a three-game sweep at Progressive Field. Steven Kwan .571 (4 for 7) and Bo Naylor .429 (3 for 7) have hit the Astros well this year. Cade Smith owns Cleveland’s only win against them this year following a solid 6 1/3-inning start by Bibee on June 8.