Israel and Iran exchange missile attacks for a third day; nuclear sites hit, death tolls rise, airspace shut, U.S. warns Tehran against retaliation.

Israeli skies were streaked with a barrage of Iranian missiles yet again on Sunday amid a spiralling conflict between the two nations. "Iran missiles incoming, sirens heard in Jerusalem," the Israel army said,

After decades of tension, a shift in the conflict between the Jewish state and Islamic Republic to open warfare is now be a real possibility.

Israeli emergency services have said at least two people were killed in the strikes and dozens of people are injured.

The exchange of fire comes as talks on Iran's nuclear program in Oman between the U.S. and Iran were called off.

The Israeli Defence Forces (IDF) on Sunday claimed it hit Iranian Defence Ministry headquarters as well as the headquarters of its nuclear project. Iran, meanwhile, launched a fresh series of missiles against Israel,

The Israeli Air Force (IAF) says it has destroyed "dozens" of radars and surface-to-air missile launchers as part of the attacks on Iran's air defence systems in the west of the country. Calling it a "large-scale strike", the IAF says this forms part of ongoing operations to damage Iran's air defence systems and those of its proxies.

Given the limited access international journalists have in Iran, the situation on the ground is largely unconfirmed.

Israel and Iran have opened a new chapter in their long history of conflict. Israel launched a major attack with strikes early Friday that set off explosions in the Iranian capital of Tehran.

Oil futures jumped as the market reopened Sunday night, building on last week’s surge after Israel attacked Iranian energy facilities over the weekend and underlining fears around potential disruption to Middle Eastern crude flows.